Successful treatment of stiff person syndrome with sequential use of tacrolimus.

Treatment of neuropathic itch possibly due to trigeminal trophic syndrome with 0.1% topical tacrolimus and gabapentin.

Stiff person case misdiagnosed as conversion disorder: A case report

Background: Stiff person syndrome (SPS) is a rare neurological disease resulting in stiffness and spasm of muscles. It initially affects the axial muscles and then spread to limb muscles. Emotional stress exacerbated the symptoms and signs of the disease. The pathophysiology of the disease is caused by the decreased level of the glutamic acid decarboxylase (GAD) activity due to an autoantibody ...

Successful intrathecal baclofen therapy for seronegative stiff-person syndrome: a case report.

We reported a 27-year-old man presenting with progressive muscle rigidity and intermittent spasms for six years. The diagnosis of stiff-person syndrome was based on the clinical features and neuroelectrophysiologic findings of continuous motor unit activities. Autoantibody against glutamic acid decarboxylase in our patient was absent either in serum or in cerebrospinal fluid. The patient was su...

Stiff Person Syndrome with Good Treatment Response to Intrathecal Baclofen

Stiff person syndrome is a rare disorder affecting the musculoskeletal system due to an underlying autoimmune process. Our case describes a 36 year old female who presented with painful, distressing, intermittent muscular rigidity and a possible associated seizure disorder. The key highlight of our case is the misdiagnosis of her disease in the early stage and the successful management of stiff...

The use of tacrolimus in the management of minimal change disease.

Kim et al [1] showed interesting results that tacrolimus and low-dose prednisolone therapy induced complete remission rapidly and effectively in adult patients with minimal change disease (MCD). MCD has been regarded as an immunological disorder. Recent works, however, have dramatically enhanced the understanding of podocyte biology, which may be the mainstay involved in the pathogenesis of MCD...